This fully updated second edition provides a comprehensive, state of the art review of renal cancer, and will serve as a guide for urology residents, clinicians, surgeons, and researchers with an interest in renal cell carcinoma. The title reviews the latest information regarding epidemiology, clinical staging, molecular biology and genetics, hereditary syndromes, pathology, imaging, molecular imaging, interventional radiology, surgical advances, and the unified approach to surgery and systemic therapy of renal cell carcinoma. It also addresses the management of localized RCC, locally advanced disease, and advanced disease.