This workbook focuses on renal replacement therapy in ICU. The incidence of acute kidney injury in critically ill patients is increasing steeply. Acute kidney injury in this setting is associated with high morbidity and mortality. There is no doubt that renal replacement therapy for the most severe forms of acute kidney injury can be life saving. The objective of this synthetic review is to present current evidence supporting best practices in renal replacement therapy for critically ill patients with acute kidney injury. This book consists of 19 chapters, which include acute kidney injury, biomarkers in acute kidney injury, renal replacement therapy: nomenclature and terminology, indications and timing of RRT in AKI, anticoagulation on RRT, acute peritoneal dialysis in critical care, chronic kidney disease patient in ICU, drug dosing on renal replacement therapy, extracorporeal therapies in sepsis, extracorporeal therapies in poisoning, nutrition for acute kidney injury patients on renal replacement therapy, and renal replacement therapy in ICU: infection control and prevention. This book fulfills an important lacuna in the field of critical care medicine in India.