The practice of hematopathology diagnostics in the modern era is a dynamic and challenging field, especially for general pathologists, junior faculty, and trainees. In addition to the ever-expanding landscape of ancillary studies, especially molecular and cytogenetic studies, two new classification schemes arrived on the scene in 2022. The new International Consensus Classification and the updated WHO 5th edition classification, offer similar but not identical frameworks for clinical diagnostic hematopathology. Additionally, distinction of reactive from neoplastic entities remains a continuous challenge in both bone marrow and lymphoid tissue. Finally, clinical hematology, which impacts the treatment of our patients, is also a continuously evolving field and it is essential to understand how to best provide diagnoses that are updated, accurate, and accessible to our clinical colleagues. This course will seek to highlight diagnostic issues raised by these recent advances through an interactive case-based format. These cases will illustrate how to interpret and apply morphologic criteria in the diagnosis of hematologic neoplasms, especially areas of ambiguity or disagreement within the two classifications. It will also highlight how to avoid diagnosing malignancy in benign mimics, and how apply ancillary testing in concert with the morphology, particularly when there are discordant or unexpected results.

This course offers digital slides for each case presented. You can view the case history and whole slide image (WSI) as unknowns by selecting Pre-session Slide Preview, or you can refer to the slides as you watch each video.

ITEMS INCLUDED IN THE PURCHASE OF THIS COURSE

Challenges in the Diagnosis of Small/Low Grade B-Cell Lymphomas – Rebecca King, MD

Section: 1 Presentation 2 Documents

Aggressive B-Cell Lymphomas-Classification Updates and Diagnostic Dilemmas – Rebecca King, MD

Section: 1 Presentation 2 Documents

Myeloma and Other Immunosecretory Disease – Megan Nakashima, MD

Section: 1 Presentation 2 Documents

Approach to the Fibrotic Bone Marrow Disease – Megan Nakashima, MD

Section: 1 Presentation 1 Document 1

Clonal Cytopenias, Myelodysplastic Syndrome (MDS), and Related Entities – Katherine Calvo, MD, PhD

Section: 1 Presentation 2 Documents

Germline Predisposition in Myeloid Neoplasia, Bone Marrow Failure, and Pediatric Myelodysplasia – Katherine Calvo, MD, PhD

Section: 1 Presentation 2 Documents

Extranodal Lymphoproliferations – James Cook, MD, PhD

Section: 1 Presentation 1 Document

T-Cell Lymphproliferations and the Utility of NGS – James Cook, MD, PhD

Section: 1 Presentation 2 Documents 1