LGBTQ individuals seek therapy at higher rates than the general population, but the mental health profession has historically lacked evidence-based guidance for supporting the unique presenting concerns of LGBTQ clients. This book changes that by presenting how-to guidance for delivering cognitive-behavioral therapy that directly responds to the distinct stressors facing LGBTQ individuals. LGBTQ-affirmative Cognitive-Behavioral Therapy is the first mental health treatment designed by and for LGBTQ individuals that has been tested in several randomized controlled trials with diverse segments of the LGBTQ community. Results of these trials show that this transdiagnostic treatment is associated with reductions in depression, anxiety, substance use problems, and psychological distress, making it suitable for a broad range of presenting concerns.