In the past few decades, neuropathology has witnessed a resurgence. The rise of structural and functional imaging techniques has allowed pathological studies to target regions of special interest as revealed by whole-brain techniques, and the development of comprehensive software packages has facilitated cellular and pathological measurements. Furthermore, a new generation of antibodies and improved staining methods has made the field more accessible to researchers and revealed more detail than could once have been envisaged. Perhaps most important of all has been the sourcing of high-quality tissue through modern, large-scale databases covering multiple tissue banks, removing much of the heterogeneity that had made repeat studies all but impossible. The Neuropathology of Schizophrenia reviews the field following these recent improvements in techniques and contrasting more modern methods against older studies.