We dedicate the current issue of the Endocrinology and Metabolism Clinics of North America to patient-reported outcomes (PROs), an emerging field in health care delivery and research. Patients’ perception about health and disease, including their quality of life (QoL) and the effects of treatment on their functional status, can be evaluated with general and disease-specific parameter instruments. Implementation of the PROs in the management of various endocrine disorder is currently unfolding and offers opportunities for improved patient-clinician communication, education, and research.