Maybury has achieved this by identifying the time and place when each operation was first undertaken. The first of these was the trephination of the skull in Peru twelve thousand years ago, presumably to exorcise evil spirits. This operation over several thousand years reached Europe where Hippocrates described and rationalised it to treat head injuries, it is still practiced today and is the forerunner of each subsequent original operation.

The golden ages of surgery took place in Ancient Greece and India and 1,300 years later in Western Europe and the USA. Between these periods, no original operations took place. Maybury explains why this happened and reveals the Greek theory that dominated surgery for over 2,000 years. He describes the passage and translation of the Greek manuscripts and their acceptance in the Arabian Empires and how in turn the Arabic versions strongly influenced Italy and then Western Europe. He also tells of the Edict of Tours of 1163 that devastated surgery and took 700 years to rectify and also the extraordinary modern era when all the tissues of the body were finally operated upon and very much more.