Neuroanatomic lesion localization - detecting where a neurologic problem arises - is key when presented with a dog or cat with signs of neurologic disease. The correct neuroanatomic lesion localization will drive veterinarians towards an appropriate list of differential diagnoses and help lead the client towards applicable diagnostic investigation. Neuroanatomic lesion localization is the first step when managing any pet with signs of neurologic disease. Despite its importance, it remains a challenge for veterinary students, residents, and practitioners in their daily practice.