This issue of Clinics in Chest Medicine, guest-edited by Dr. Aaron B Waxman and Dr. Inderjit Singh, is focused on Pulmonary Hypertension. Topics discussed in this issue include but are not limited to: Integrative omics to characterize and classify pulmonary vascular disease, Contemporary Pharmacotherapeutic Approach in Pulmonary Arterial Hypertension, Personalized Medicine: The Future Management of Pulmonary Hypertension Requires A New Taxonomy, Sex differences in Pulmonary Hypertension and Pulmonary Hypertension in Pregnancy