A comprehensive guide to reproductive medicine students and practicing clinicians dealing with cases of infertility in the setting of medical disorders. •Discusses the management of infertility with medical disorders such as heart disease, coagulation disorder, renal disease, and women post-transplant, etc. •The content is written by reproductive medicine specialists experienced in the field of fertility and ART.•Provides the best possible guidance to the treating doctors and the students to manage these complex scenarios.