Youths who are negatively affected by social determinants of health suffer adverse effects like increased risks of chronic health conditions and mental health issues. Part 3 of this series describes ways pediatricians can help fight these social determinants to promote health equity for our most vulnerable children. The causes and effects of social determinants of health are well-documented. Individual and group interventions such as screening, establishing community partnerships and a culture of diversity, equity, and inclusion, and eliminating barriers to quality health care are highlighted in this collection and can go a long way toward ensuring that all children get the care they deserve.