This issue of Neurologic Clinics, edited by Drs. Russell E. Bartt and Allen J. Aksamit, Jr., will focus on Neuro-Infectious Diseases. Topics include, but are not limited to, Acute Community and Nosocomial Meningitis; Viral Encephalitis and Post-infectious Autoimunnity; Spine and spinal cord infections; Chronic meningitis; Manifestations of Herpes Virus Infections in the Nervous System; HIV and Nervous System; Neuroborreliosis; Progressive Multifocal Leukoencephalopathy; Zika Virus and Neurological Disease; Neurocysticercosis; Prion Disease; and Diagnostic Testing of Neurological Infections.