This book will guide clinicians to achieve great results with L-PRF. It starts with basic science chapters on tissue regeneration, blood centrifugation, and an explanation of the biologic power of platelet concentrates. However, the true value of this book lies in an evidence-based evaluation of the benefits of L-PRF in periodontal and maxillofacial surgery, as well as in chronic wound therapy. For each treatment, a step-by-step approach has been created by experienced clinicians. The most crucial steps are explained in 18 videos via augmented reality. 830 illustrations. Contents: Part A. Basic Science and Preparation of L-PRF 1. Blood Composition and Cellular Characteristics 2. Wound Healing 3. Centrifugation of Blood via Specific L-PRF Protocols 4. General Characteristics and Mode of Action of L-PRF Membranes 5. Potential Role of L-PRF in Periodontal Regeneration 6. Preparation of Various L-PRF Constructs Part B. Clinical Applications of L-PRF 7. L-PRF as Substitute for Ridge Preservation 8. The Use of L-PRF in Sinus Therapy 9. The Use of L-PRF During Bone Regeneration Procedures 10. Implant Coating with L-PRF to Facilitate Osseointegration 11. L-PRF to Promote the Regeneration of Intrabony Defects Around Teeth 12. The Use of L-PRF for Periodontal Plastic Surgery 13. L-PRF in the Management of Peri-Implantitis 14. L-PRF for the Management of MRONJ 15. L-PRF Soft-Blocks for Ridge Preservation in Sockets with Major Bone Defects 16. Step-by-Step Protocols 17. L-PRF for Extraoral Wounds Epilogue