This book will cover all areas concerning the high bleeding risk and fragile patients (including CHIP). This milieu is becoming more and more common and requires specific attention and investment from the healthcare systems to be managed properly. The book will be divided into 4 macro-areas (coronary artery disease, valvular heart disease, peripheral arterial disease, high thrombotic risk patients), each of which include specific chapters on the latest technical advances, offering a thorough literature coverage as well. Additional sections are devoted to future diagnostic and therapeutic areas, depending on the disease and the patient's risk profile. Interventional cardiologists and cardiac surgeons dealing with PCI, coronary bypasses, left atrial appendage closure, aortic and mitral interventions in this patient subgroup will be provided with an overview of the latest techniques and innovative technologies in this area, that will help them improving the clinical outcome of their patients. The invited group of collaborators was selected from among the most experienced physicians in the world, from Asia, North and South America and Europe.