AABB and SABM have jointly developed this collection of clinical scenarios that typify the situations faced by those involved in patient care. Case Studies in Patient Blood Management is a resource for anyone interested in patient-centered care—including clinicians, nurses, laboratory technologists, and pharmacists. Other health-care personnel such as ethicists and risk managers will benefit from this collection of typical clinical situations, developed jointly by AABB and SABM. Each scenario features learning objectives, a clinical situation, a discussion of patient blood management options, the evidence that supports each PBM approach discussed, and a listing of key points and references. Within that framework, each expert author contributes to a rich diversity of PBM options that are intended to stimulate thought and discussion, leading to improved patient care and clinical outcomes.