This compilation includes eleven chapters detailing various advances in neuropathology. Chapter One includes a quantitative study concerning the spectrum of temporal lobe pathology in argyrophilic grain disease. Chapter Two discusses the clinical, pathologic, and recent genetic features of pineoblastoma tumors. Chapter Three describes the clinical and histopathological features of spinal ependymomas, focusing on the current approach to treatment. Chapter Four defines the clinical and molecular pathological hallmarks of diffuse intrinsic pontine glioma and explores various therapies for treatment. Chapter Five reviews the clinicopathologic and genetic features of supratentorial ependymomas. Chapter Six reviews various features of astroblastoma. Chapter Seven explores the clinical, pathology, and genetic features of pilocytic astrocytomas. Chapter Eight describes rare, benign brain tumors called craniopharyngiomas. Chapter Nine reviews the clinicopathologic features of primary amoebic meningoencephalitis and how it is impacted by climate change. Chapter Ten deals with a rare cerebral hemispheric tumor with characteristics often resembling grade 4 astrocytoma. Finally, Chapter Eleven details the clinicopathologic features of myxoid glioneuronal tumors.